Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes
| Autor: | Liher Prieto, Mark Lautens, Bijan Mirabi, Andrew Whyte, José F. Rodríguez, Alexa Torelli |
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| Rok vydání: | 2020 |
| Předmět: |
Chemistry
Intermolecular force Enantioselective synthesis chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis Domino 0104 chemical sciences Colloid and Surface Chemistry Structural isomer Reactivity (chemistry) Cobalt Bond cleavage |
| Zdroj: | Journal of the American Chemical Society. 142:9510-9517 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/jacs.0c03246 |
| Popis: | An asymmetric hydroarylative cyclization of enynes involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermolecular C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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