Effects of two probiotic spores of Bacillus species on hematological, biochemical, and inflammatory parameters in Salmonella Typhimurium infected rats
| Autor: | Azadeh Yektaseresht, Seyed Shahram Shekarforoush, Masoumeh Honarmand, Sara Basiri, Saeed Nazifi, Somaye Mazkour |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Erythrocyte Indices Salmonella typhimurium Salmonella medicine.drug_class 030106 microbiology Antibiotics lcsh:Medicine Spleen Bacillus Bacillus subtilis medicine.disease_cause Article Antioxidants Microbiology law.invention Applied microbiology 03 medical and health sciences Cecum Probiotic law medicine Mesenteric lymph nodes Animals lcsh:Science Spores Bacterial Salmonella Infections Animal Multidisciplinary biology Probiotics lcsh:R biology.organism_classification Bacterial Load Rats 030104 developmental biology medicine.anatomical_structure Microbial Interactions Bacillus coagulans lcsh:Q Bacterial infection Inflammation Mediators Reactive Oxygen Species Biomarkers Blood Chemical Analysis |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Salmonella infections have become a major health concern in recent decades. This pathogen has evolved to become resistant to antibiotics, which has caused problems in its treatment. As such, finding a novel preventive method is important in the treatment and management of this infection. In recent years, uses of probiotics, especially spore-former genera such as Bacillus spp. has become increasingly popular. In this study spores of two probiotic bacteria, Bacillus subtilis and Bacillus coagulans were fed to rats for three weeks through their daily water intake after which Salmonella Typhimurium was gavaged to the rats. On days 1, 3, 5 and 7 after gavaging, the number of Salmonella was counted in liver, spleen, mesenteric lymph nodes, feces and content of ileum and cecum. Hematological and biochemical parameters, inflammatory mediators, total antioxidant capacity and malondialdehyde were also measured. The results showed that B. subtilis and B. coagulans caused delation in infiltration of Salmonella into the lymph nodes, spleen and liver, reduction of the inflammatory mediators, and decreases in oxidative stress, hematological and biochemical changes. The overall count of Salmonella in the above mentioned parameters has also decreased and a faster return to normal base were also witnessed. The results showed that the use of B. subtilis and B. coagulans can potentially help boost the body’s immune system, to combat the effects of exposure to the Salmonella pathogen. |
| Databáze: | OpenAIRE |
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