Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: a self-controlled study

Autor:	Jibing Chen, Wei Qian, You-Yong Lu, Kecheng Xu, Tian-Yu Lu, Xiao-Feng Kong, Feng Mu
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Male gamma delta T cell Lung Neoplasms T cell Neuroscience (miscellaneous) Adaptive Immunity Natural killer cell Immune system hydrogen inhalation Carcinoma Non-Small-Cell Lung Administration Inhalation medicine Cytotoxic T cell Humans Gamma delta T cell non-small cell lung cancer immunosenescence business.industry Immunosenescence natural killer cell Middle Aged Natural killer T cell adaptive and innate immune system Immunity Innate natural killer T cell Anesthesiology and Pain Medicine medicine.anatomical_structure Peripheral blood lymphocyte Immunology Female business Research Article Hydrogen
Zdroj:	Medical Gas Research
ISSN:	2045-9912
Popis:	Following standard treatments, the traditional model for enhancing anti-tumor immunity involves performing immune reconstitution (e.g., adoptive immune cell therapies or immunoenhancing drugs) to prevent recurrence. For patients with advanced non-small cell lung cancer, we report here on two objectives, the immunosenescence for advanced non-small cell lung cancer and hydrogen gas inhalation for immune reconstitution. From July 1st to September 25th, 2019, 20 non-small cell lung cancer patients were enrolled to evaluate the immunosenescence of peripheral blood lymphocyte subsets, including T cell, natural killer/natural killer T cell and gamma delta T cell. Two weeks of hydrogen inhalation was performed during the waiting period for treatment-related examination. All patients inhaled a mixture of hydrogen (66.7%) and oxygen (33.3%) with a gas flow rate of 3 L/min for 4 hours each day. None of the patients received any standard treatment during the hydrogen inhalation period. After pretreatment testing, major indexes of immunosenescence were observed. The abnormally higher indexes included exhausted cytotoxic T cells, senescent cytotoxic T cells, and killer Vδ1 cells. After 2 weeks of hydrogen therapy, the number of exhausted and senescent cytotoxic T cells decreased to within the normal range, and there was an increase in killer Vδ1 cells. The abnormally lower indexes included functional helper and cytotoxic T cells, Th1, total natural killer T cells, natural killer, and Vδ2 cells. After 2 weeks of hydrogen therapy, all six cell subsets increased to within the normal range. The current data indicate that the immunosenescence of advanced non-small cell lung cancer involves nearly all lymphocyte subsets, and 2 weeks of hydrogen treatment can significantly improve most of these indexes. The study was approved by the Ethics Committee of Fuda Cancer Hospital, Jinan University in China (approval No. Fuda20181207) on December 7th, 2018, and was registered on ClinicalTrials.gov (ID: NCT03818347) on January 24th, 2019.
Databáze:	OpenAIRE
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