Pharmacokinetics, Short-term Safety and Efficacy of the Approved Once-daily Darunavir/Ritonavir Dosing Regimen in HIV-infected Children
| Autor: | Angela Colbers, Eline G. Visser, David M. Burger, Clementien L. Vermont, Annemarie M. C. van Rossum, Michiel van der Flier, Sibyl P. M. Geelen, Diane E. T. Bastiaans, Monique Roukens |
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| Přispěvatelé: | Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Pediatrics medicine.medical_specialty Darunavir+Ritonavir 030106 microbiology lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] HIV Infections darunavir once-daily Drug Administration Schedule 03 medical and health sciences 0302 clinical medicine Pharmacotherapy Pharmacokinetics SDG 3 - Good Health and Well-being children medicine Humans DRUGS 030212 general & internal medicine Dosing Child Darunavir Ritonavir business.industry Dosing regimen HIV HIV Protease Inhibitors lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Infectious Diseases Pediatrics Perinatology and Child Health HIV-1 Drug Therapy Combination Female Once daily business pharmacokinetics medicine.drug |
| Zdroj: | Pediatric Infectious Disease Journal, 37(10), 1008-1010. Lippincott Williams & Wilkins Pediatric infectious disease journal, 37(10), 1008-1010. LIPPINCOTT WILLIAMS & WILKINS Pediatric Infectious Disease Journal, 37(10), 1008. Lippincott Williams and Wilkins Pediatric Infectious Disease Journal, 37, 10, pp. 1008-1010 Pediatric Infectious Disease Journal, 37, 1008-1010 |
| ISSN: | 0891-3668 |
| Popis: | Contains fulltext : 196133.pdf (Publisher’s version ) (Closed access) In this multicenter pharmacokinetic study in HIV-infected children (6-12 years of age), we validated the approved once-daily darunavir/ritonavir dosing recommendations. The geometric mean darunavir area under the plasma concentration-time curve was 63.1 h.mg/L, substantially lower than the mean value observed in adults. However, all trough levels were adequate, and short-term virologic outcome was good. These data support the use of the darunavir/ritonavir once-daily dosing recommendations. |
| Databáze: | OpenAIRE |
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