The Donor-Risk-Index, ECD-Score and D-MELD-Score all fail to predict short-term outcome after liver transplantation with acceptable sensitivity and specificity
| Autor: | Jürgen Klempnauer, Hüseyin Bektas, Harald Schrem, Nils Frühauf, Moritz Kleine, Thomas Becker, Frank Lehner, B. Reichert, Lea Zachau |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Reoperation Risk medicine.medical_specialty Pathology Adolescent medicine.medical_treatment Youden's J statistic Liver transplantation Sensitivity and Specificity Severity of Illness Index Predictive Value of Tests Risk index Internal medicine Clinical endpoint Medicine Humans Aged Transplantation Receiver operating characteristic business.industry Graft Survival Patient survival General Medicine Middle Aged Liver Transplantation Treatment Outcome Female Adult liver business Liver Failure |
| Zdroj: | Annals of transplantation. 17(3) |
| ISSN: | 2329-0358 |
| Popis: | BACKGROUND Expansion of the donor pool by the use of grafts with extended donor criteria reduces waiting list mortality with an increased risk for graft and patient survival after liver transplantation. This study investigates the ability of the Donor-Risk-Index (DRI), the Extended-Criteria-Donor-Score (ECD-score) and the D-MELD-score to predict early outcome after liver transplantation. MATERIAL/METHODS 291 consecutive adult liver transplants (01.01.2007-31.12.2010) were analysed in a single centre study with ongoing data collection. Primary study endpoints were 30-day mortality, 3-month mortality, 3-month patient and graft survival and the necessity of acute retransplantation within 30 days. For the primary study endpoints ROC-curve analysis was performed to calculate the sensitivity, specificity, and overall model correctness of the Donor-Risk-Index (DRI), Extended-Criteria-Donor-Score (ECD-score) and the D-MELD-Score as predictive models. Cut-off values were selected with the best Youden index. RESULTS ROC-curve analysis showed areas under the curve (AUROCs) |
| Databáze: | OpenAIRE |
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