Effects of treatment in hypertension results of a controlled study
| Autor: | Robert D. Lindeman, Frederick W. Wolff |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Adult
Guanethidine Male medicine.medical_specialty Reserpine Epidemiology Population Thiazines Placebo group White People Placebos Treatment and control groups Internal medicine medicine Humans In patient Intensive care medicine education Thiazide Aged Clinical Trials as Topic education.field_of_study Maryland business.industry Serum uric acid Middle Aged Uric Acid Black or African American Blood Supportive psychotherapy Hypertension Carbohydrate Metabolism Female business Follow-Up Studies medicine.drug Clearance |
| Zdroj: | Journal of Chronic Diseases. 19:227-240 |
| ISSN: | 0021-9681 |
| DOI: | 10.1016/0021-9681(66)90128-7 |
| Popis: | Morbidity, mortality, and target organ function have been followed in a double-blind study of a predominantly Negro clinic population with mild to moderately severe hypertension over a 2-year period. Patients were placed randomly on either hypotensive drug therapy (reserpine, thiazide, guanethedine) or matched placebos. There were 6 treatment failures among 45 patients in the treatment group and 19 failures among 42 patients in the placebo group. All but one of the failures in the placebo group improved or cleared upon early institution of appropriate hypertensive and supportive therapy. Abnormalities in carbohydrate metabolism and serum uric acid levels were found in patients receiving long-term thiazide therapy. Hypertensive disease in the Negro population of Baltimore is a serious, life-threatening condition. Our study provides evidence of the need for continuous close supervision, and the provision of organized teams devoted to the care, of such a population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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