Efficacy of Binary Media and Gold Catalyst for the Synthesis of a Conjugates with Cyclohexyl-Tetrazole-Alkyloxyphenyl-Benzenamine through Ugi 4-CC Reactions: Cytotoxic and Single-Crystal Studies
| Autor: | Amita Jivani, Khushal Kapadiya, Agnieszka Jainik, Ranjan Khunt |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Polycyclic Aromatic Compounds. :1-15 |
| ISSN: | 1563-5333 1040-6638 |
| Popis: | With the critical increase in patients suffering from various types of malignant growth, it is obvious that quick steps in the development of novel and viable agents should be taken. In the current study, we focused on a novel synthetic approach for the synthesis of tetrazole derivatives using Ugi-4CR by employing a gold catalyst in water: methanol media. Gold’s adjustable nature, unique characteristics, and mild reaction conditions were utilized to generate a quadrupole adduct containing a cyclohexyl system, benzamine, terminal alkyne bearing aryl and a medicinally efficient tetrazole fragment. Along with the routine characteristic techniques (IR, MS, NMR), single crystal XRD was imparted for the assumption of the spatial arrangement of the desired adduct (5a-5j). Out of 10 selected scaffolds for the NCI 60 cell lines study, 5b was shown their highest potency in the single-dose assay (10−4 M) against CAKI-1 (GI50= −4.66, Renal cancer) and 5e were found to be most active in Leukemia (MOLT-4, GI50= −5.37) cancers than the rest of synthesized molecules. |
| Databáze: | OpenAIRE |
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