Exploration of the Impact of Brief Noninvasive Vagal Nerve Stimulation on EEG and Event-Related Potentials
| Autor: | Nitin Bangera, Kim Paulson, Jeffrey D. Lewine, Bruce J. Simon |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Vagus Nerve Stimulation Mismatch negativity Stimulation Electroencephalography Young Adult 03 medical and health sciences 0302 clinical medicine Event-related potential medicine Humans Evoked Potentials Sensory gating medicine.diagnostic_test business.industry Solitary tract Brain General Medicine Middle Aged Electrophysiology Anesthesiology and Pain Medicine medicine.anatomical_structure Neurology Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Acetylcholine medicine.drug |
| Zdroj: | Neuromodulation: Technology at the Neural Interface. 22:564-572 |
| ISSN: | 1094-7159 |
| Popis: | OBJECTIVES The primary objective of this study was to explore the impact of noninvasive Vagal Nerve Stimulation (nVNS) on brain electrophysiology, as assessed through spontaneous resting-state EEG and stimulus-driven event-related potentials (ERPs). METHODS A hand-held transcutaneous stimulator was placed on the neck over the main branch of the left vagus (active condition) or more laterally over neck muscles (sham condition), with two 120-sec long bursts of stimulation applied over a five-minute period. For each of eight neurotypical subjects, prior to stimulation, and then again beginning at 15, 120, and 240 min post-stimulation, ten minutes of background EEG data were collected, along with a series of ERPs-N100 auditory sensory-gating; the N1/P2 loudness dependent auditory evoked responses (LDAER); mismatch negativity; P300a; and P300b. Each subject participated in active and sham stimulation sessions. RESULTS Brief nVNS had a significant (p 2 hours), impact on the spontaneous EEG (decreased theta and alpha, and increased beta and gamma), and on sensory gating, LDAER, and P300b evoked responses. Based on prior literature, these specific observations may reflect nVNS-induced modulation of particular neurotransmitter systems including those for GABA (gamma power and frequency); acetylcholine (sensory gating); serotonin (LDAER); and noradrenaline (P300b). CONCLUSIONS Brief nVNS leads to changes in a sub-set of resting-state and event-related electrophysiologic indices of brain activity. These changes are believed to be mediated by vagal afferent projections to the nucleus of the solitary tract, which in turn regulates several neurotransmitter systems through known direct and indirect neuroanatomic pathways. |
| Databáze: | OpenAIRE |
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