Wheezing phenotypes in young children: an historical cohort study
| Autor: | Alfredo Cano-Garcinuño, Isabel Mora-Gandarillas, Ángeles Cobo-Ruisánchez, Ignacio Pérez-Candás, Castañón-Rodríguez Carmen, Isabel Carballo-Castillo, Aidé Aladro-Antuña, Felipe Gonzáez-Rodríguez, Zoa García-Amorín, Luís Miguel Fernández-Cuesta, María García-Adaro, Agustina Alonso-Álvarez, María Ángeles Ordóñez-Alonso, Francisco Fernández-Ló\pez, Fernando Nuño-Martín, Rosa Rodríguez-Posada, Milagros Moreno-Sierra, Mar Coto-Fuente, Luz María Alonso-Bernardo, Leonor Merino-Ramos, Rosa Buznego-Sánchez, Ana Pérez-Vaquero, María Luisa García-Balbuena, María Fernández-Francés, Carolina Ruano-Fajardo, Begoña Domínguez-Aurrecoechea, Ignacio Carvajal-Urueña, Ana Arranz-Velasco, Águeda García-Merino, Yáñez-Meana Begoña, Encarnación Díaz Estrada, Ángel Costales-Álvarez |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Pediatrics medicine.medical_specialty cohort studies Wheeze Humans Medicine Respiratory sounds Asthma child medicine.diagnostic_test business.industry Incidence (epidemiology) Public Health Environmental and Occupational Health asthma medicine.disease infant Latent class model respiratory sounds Natural history Phenotype Female medicine.symptom business Historical Cohort Research Paper Cohort study |
| Zdroj: | Primary Care Respiratory Journal: Journal of the General Practice Airways Group |
| ISSN: | 1475-1534 1471-4418 |
| Popis: | Background: Wheezing phenotypes in young children have usually been described on the basis of questionnaire surveys instead of prospectively doctor-diagnosed episodes, and have never been described in terms of incidence rates. Aims: To identify wheezing phenotypes in the first three years and describe their incidence trends, and to investigate their relationship with asthma at six years of age. Methods: Doctor-diagnosed wheezing episodes in the first 36 months and active asthma at six years were identified in a historical cohort of 3,739 children followed from birth in 29 primary care health centres in Spain. Wheezing phenotypes were identified by means of latent class analysis. Changes in incidence rates of wheezing were identified through joinpoint regression models and their predictive ability for asthma was analysed. Results: One never/infrequent wheeze phenotype and three wheezing phenotypes were identified. There were two early phenotypes which started wheezing at a median age of six months, one of which was transient while the other had a heavy recurrence of episodes. A third phenotype exhibited a delayed onset of wheezing, a constant rise in incidence through the first 36 months, and a relationship with allergic asthma. These three phenotypes had a higher prevalence of active asthma at six years than the never/infrequent wheeze phenotype, but the classification had a weak predictive ability for asthma due to low sensitivity. Conclusions: The use of incidence rates contributes to the clarification of the natural history of infant wheezing. |
| Databáze: | OpenAIRE |
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