Surface-Adaptive and Initiator-Loaded Graphene as a Light-Induced Generator with Free Radicals for Drug-Resistant Bacteria Eradication
| Autor: | Xunzhou Yu, Danfeng He, Ximu Zhang, Hongmei Zhang, Jinlin Song, Dezhi Shi, Yahan Fan, Gaoxing Luo, Jun Deng |
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| Rok vydání: | 2018 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Mice Inbred BALB C Indoles Light Polymers 3T3 Cells 02 engineering and technology Staphylococcal Infections 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Anti-Bacterial Agents 0104 chemical sciences Mice Photochemotherapy Drug Resistance Multiple Bacterial Animals Humans Graphite General Materials Science Reactive Oxygen Species 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 11:1766-1781 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.8b12873 |
| Popis: | Since generating toxic reactive oxygen species is largely dependent on oxygen, bacteria-infected wounds' hypoxia significantly inhibits photodynamic therapy's antibacterial efficiency. Therefore, a novel therapeutic method for eradicating multidrug-resistant bacteria is developed based on the light-activated alkyl free-radical generation (that is oxygen independent). According to the polydopamine-coated carboxyl graphene (PDA@CG), an initiator-loaded and pH-sensitive heat-producible hybrid of bactericides was synthesized. According to fluorescence/thermal imaging, under the low pH of the bacterial infection sites, this platform turned positively charged, which allows their accumulation in local infection site. The plasmonic heating effects of PDA@CG can make the initiator decomposed to generate alkyl radical (R |
| Databáze: | OpenAIRE |
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