Effects of chronic gap junction conduction-enhancing antiarrhythmic peptide GAP-134 administration on experimental atrial fibrillation in dogs
| Autor: | Xudong Hu, Paul Dorian, Emidio Tarulli, Gabriel Laurent, Howard Leong-Poi, Andrew Ramadeen, Iqwal Mangat, Petsy Pui-Sze So, Gordon W. Moe, James K. Hennan, Eric I. Rossman |
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| Rok vydání: | 2009 |
| Předmět: |
Heart disease
Proline Refractory Period Electrophysiological medicine.medical_treatment Cardiomyopathy Administration Oral Antiarrhythmic agent Placebo Dogs Oral administration Heart Conduction System Physiology (medical) Atrial Fibrillation medicine Animals Heart Atria biology business.industry Fissipedia Cardiac Pacing Artificial Gap Junctions Atrial fibrillation medicine.disease biology.organism_classification Fibrosis Immunohistochemistry Disease Models Animal Anesthesia Connexin 43 Circulatory system Benzamides Cardiology and Cardiovascular Medicine business Anti-Arrhythmia Agents |
| Zdroj: | Circulation. Arrhythmia and electrophysiology. 2(2) |
| ISSN: | 1941-3084 |
| Popis: | Background— Abnormal intercellular communication caused by connexin dysfunction may contribute to atrial fibrillation (AF). The present study assessed the effect of the gap junction conduction–enhancing antiarrhythmic peptide GAP-134 on AF inducibility and maintenance in a dog model of atrial cardiomyopathy. Methods and Results— Twenty-four dogs subject to simultaneous atrioventricular pacing (220 bpm for 14 days) were randomly assigned to placebo treatment (PACED-CTRL; 12 dogs) or oral GAP-134 (2.9 mg/kg BID; PACED-GAP-134; 12 dogs) starting on day 0. UNPACED-CTRL (4 dogs) and UNPACED-GAP-134 (4 dogs) served as additional control groups. Change in left atrial (LA) systolic area from baseline to 14 days was calculated using transoesophageal echocardiography. At 14 days, animals underwent an open-chest electrophysiological study. PACED-CTRL dogs (versus UNPACED-CTRL) had a shorter estimated LA wavelength (8.0�1.4 versus 24.4�2.5 cm, P P P P Conclusions— Oral GAP-134 reduces pacing-induced decrease in LA wavelength and appears to attenuate AF vulnerability in dogs with less atrial mechanical remodeling. Gap junction modulation may affect AF in some circumstances. |
| Databáze: | OpenAIRE |
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