Human Monkeypox Outbreak Caused by Novel Virus Belonging to Congo Basin Clade, Sudan, 2005
| Autor: | M Opoka, Elmangory M. Mutasim, Alimagboul A. Babiker, Thomas Rioton, Sharlenna Wang, Thierry Durand, Mamunur Rahman Malik, Vipul Chowdhary, Mohammed O. Muntasir, Magdi S. Abdalla, Mubarak E. M. Karsani, Inger K. Damon, Kevin L. Karem, Jean-Claude Manuguerra, Whitni Davidson, Andrea Kuong-Ruay, Pierre Formenty, Abdalhalim Khalid, Jeanne Cabeza, Charlotte Monimart |
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| Přispěvatelé: | Global Alert and Response Department (HSE/GAR), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Federal Ministry of Health [Khartoum], Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Médecins Sans Frontières [Paris] (MSF), National Laboratory of Public Health, Cellule d'Intervention Biologique d'Urgence - Laboratory for Urgent Response to Biological Threats (CIBU), Institut Pasteur [Paris] (IP), Minister of Health of Unity State, We thank the Ministry of Health of Unity State, the Federal Ministry of Health of Sudan, Médecins-Sans-Frontières France, Action-Contre-la-Faim, Cooperative for Assistance and Relief Everywhere (CARE), World Food Programme, Office for the Coordination of Humanitarian Affairs, and United Nations Development Programme for their assistance during this outbreak investigation. We also thank Cody Clemmons, Hui Zhao, Yu Li, Scott Schmid, and Kay Radford for laboratory analysis of specimens. |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent human transmission [SDV]Life Sciences [q-bio] Prevalence lcsh:Medicine orthopoxvirus Antibodies Viral Polymerase Chain Reaction Virus Disease Outbreaks lcsh:Infectious and parasitic diseases Sudan Young Adult Monkeypox medicine Animals Humans viruses lcsh:RC109-216 Monkeypox virus Child Clade biology outbreak Transmission (medicine) Research lcsh:R Infant Outbreak zoonosis biology.organism_classification medicine.disease Virology Infectious Diseases Congo Immunoglobulin M Child Preschool Immunoglobulin G Novel virus Female epidemiology |
| Zdroj: | Emerging Infectious Diseases, Vol 16, Iss 10, Pp 1539-1545 (2010) Emerging Infectious Diseases Emerging Infectious Diseases, 2010, 16 (10), pp.1539-1545. ⟨10.3201/eid1610.100713⟩ |
| ISSN: | 1080-6059 1080-6040 |
| Popis: | TOC Summary: This virus should be considered endemic to the wetland areas of Bentiu, Unity State, Sudan. To determine the outbreak source of monkeypox virus (MPXV) infections in Unity State, Sudan, in November 2005, we conducted a retrospective investigation. MPXV was identified in a sub-Sahelian savannah environment. Three case notification categories were used: suspected, probable, and confirmed. Molecular, virologic, and serologic assays were used to test blood specimens, vesicular swabs, and crust specimens obtained from symptomatic and recovering persons. Ten laboratory-confirmed cases and 9 probable cases of MPXV were reported during September–December 2005; no deaths occurred. Human-to-human transmission up to 5 generations was described. Our investigation could not fully determine the source of the outbreak. Preliminary data indicate that the MPXV strain isolated during this outbreak was a novel virus belonging to the Congo Basin clade. Our results indicate that MPXV should be considered endemic to the wetland areas of Unity State. This finding will enhance understanding of the ecologic niche for this virus. |
| Databáze: | OpenAIRE |
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