Clavatadines C−E, Guanidine Alkaloids from the Australian Sponge Suberea clavata

Autor:	Malcolm Stewart Buchanan, Michael F. Jobling, Anthony R. Carroll, Rohan A. Davis, Vicky M. Avery, John N. A. Hooper, Deborah Wessling, Ronald J. Quinn, Yunjiang Feng
Rok vydání:	2009
Předmět:	Stereochemistry Pharmaceutical Science Marine Biology Pharmacognosy Guanidines Factor XIa Analytical Chemistry chemistry.chemical_compound Alkaloids Drug Discovery Animals Guanidine Nuclear Magnetic Resonance Biomolecular Pharmacology Serine protease chemistry.chemical_classification Molecular Structure biology Alkaloid Organic Chemistry Australia Biological activity biology.organism_classification Porifera Sponge Enzyme Complementary and alternative medicine chemistry biology.protein Molecular Medicine Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Journal of Natural Products. 72:973-975
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np8008013
Popis:	Three new marine alkaloids, clavatadines C-E (1-3), together with the three known compounds aerophobin 1 (4), purealdin L (5), and aplysinamisine II (6) were isolated from extracts of the sponge Suberea clavata by bioassay-guided fractionation using a serine protease factor XIa assay. Their structures were determined by 1D and 2D NMR spectroscopy. Compounds 1-6 exhibited weak inhibition of factor XIa.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb529687612a325774e0ebd422b8682 https://doi.org/10.1021/np8008013 Zobrazit plný text záznamu