Pharmacological Effects of Active Compounds on Neurodegenerative Disease with Gastrodia and Uncaria Decoction, a Commonly Used Poststroke Decoction
| Autor: | Stanley C. C. Chik, Terry C. T. Or, Cindy L.H. Yang, Allan S. Y. Lau, D. Luo |
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| Rok vydání: | 2013 |
| Předmět: |
lcsh:Medicine
Decoction Review Article Traditional Chinese medicine Disease Pharmacology lcsh:Technology General Biochemistry Genetics and Molecular Biology Therapeutic approach High morbidity Gastrodia Animals Humans Medicine Medicine Chinese Traditional lcsh:Science General Environmental Science Inflammation biology Traditional medicine lcsh:T business.industry lcsh:R Neurodegenerative Diseases General Medicine biology.organism_classification Stroke in China Tracheophyta Uncaria lcsh:Q business Drugs Chinese Herbal |
| Zdroj: | The Scientific World Journal, Vol 2013 (2013) The Scientific World Journal |
| ISSN: | 1537-744X |
| Popis: | Neurodegenerative diseases refer to the selective loss of neuronal systems in patients. The diseases cause high morbidity and mortality to approximately 22 million people worldwide and the number is expected to be tripled by 2050. Up to now, there is no effective prevention and treatment for the neurodegenerative diseases. Although some of the clinical therapies target at slowing down the progression of symptoms of the diseases, the general effectiveness of the drugs has been far from satisfactory. Traditional Chinese medicine becomes popular alternative remedies as it has been practiced clinically for more than thousands of years in China. As neurodegenerative diseases are mediated through different pathways, herbal decoction with multiple herbs is used as an effective therapeutic approach to work on multiple targets. Gastrodia and Uncaria Decoction, a popular TCM decoction, has been used to treat stroke in China. The decoction contains compounds including alkaloids, flavonoids, iridoids, carotenoids, and natural phenols, which have been found to possess anti-inflammatory, antioxidative, and antiapoptotic effects. In this review, we will summarize the recent publications of the pharmacological effects of these five groups of compounds. Understanding the mechanisms of action of these compounds may provide new treatment opportunities for the patients with neurodegenerative diseases. |
| Databáze: | OpenAIRE |
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