Astrocytes and neurons share brain region-specific transcriptional signatures
| Autor: | Verónica Moreno-Juan, Laia Torres-Masjoan, Marisa Karow, Eduardo Leyva-Díaz, Alvaro Herrero-Navarro, José P. López-Atalaya, Laura López-Mascaraque, Alejandro Sempere-Ferràndez, Rafael Susín, Guillermina López-Bendito, Ana Espinosa, Benedikt Berninger, Lorenzo Puche-Aroca, María Figueres-Oñate |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Neocortex Cell Thalamus Biology 03 medical and health sciences Brain region 0302 clinical medicine medicine.anatomical_structure nervous system Gene expression medicine Epigenetics Progenitor cell Reprogramming Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/2020.04.21.038737 |
| Popis: | SUMMARYNeuronal cell diversity is essential to endow distinct brain regions with specific functions. During development, progenitors within these regions are characterised by specific gene expression programs, contributing to the generation of diversity in postmitotic neurons and glia. While the region-specific molecular diversity of neurons and astrocytes is increasingly understood, whether these cells share region-specific programs remains unknown. Here, we show that in the neocortex and thalamus, neurons and astrocytes express shared region-specific transcriptional and epigenetic signatures. These signatures not only distinguish cells across brain regions but are also detected across substructures within regions, such as distinct thalamic nuclei, where clonal analysis revealed the existence of common nucleus-specific progenitors for neurons and glia. Consistent with their shared molecular signature, regional specificity was maintained following astrocyte-to-neuron reprogramming. A detailed understanding of these regional-specific signatures may thus inform strategies for future cell-based brain repair. |
| Databáze: | OpenAIRE |
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