Conserved sequences in bacterial and viral sialidases
| Autor: | Bernd Rothe, Eric R. Vimr, James B. Kaper, Lois Lawrisuk, James E. Galen, Peter Roggentin, Roland Schauer |
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| Rok vydání: | 1989 |
| Předmět: |
Salmonella typhimurium
Genes Viral Clostridium perfringens Molecular Sequence Data Clostridium sordellii medicine.disease_cause Sialidase Biochemistry Microbiology Conserved sequence Clostridium Sequence Homology Nucleic Acid medicine Influenza A virus Amino Acid Sequence Vibrio cholerae Molecular Biology Peptide sequence Gene Viral Structural Proteins biology Cell Biology biology.organism_classification Biological Evolution Genes Bacterial |
| Zdroj: | Glycoconjugate Journal. 6:349-353 |
| ISSN: | 1573-4986 0282-0080 |
| Popis: | The genes of the bacterial sialidases from Clostridium sordellii G12, C. perfringens A99, Salmonella typhimurium LT-2 and Vibrio cholerae 395 sequenced so far were examined for homologies and were compared with sequences of viral sialidases. Each of the bacterial sialidases contains a short sequence of twelve amino-acids, which is repeated at four positions in the protein. All these sequences exhibit significant similarities. Comparing the repeated sequences of the four sialidases, five amino-acids were found to be highly conserved at defined positions: Ser-X-Asp-X-Gly-X-Thr-Trp. Additionally, most of the distances between the four repeated regions are also conserved among the different sialidases. The conserved bacterial sequences show similarity with sialidases of influenza A H7N1 and H13N9. |
| Databáze: | OpenAIRE |
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