Trichomoniasis and its treatment
| Autor: | George Kurdgelashvili, Karen A. Wendel, Neha Nanda, Ross G Michel |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Sexually Transmitted Diseases Trichomonas Infections Antitrichomonal Agents medicine.disease_cause Microbiology chemistry.chemical_compound Trichomonas Vaginitis Pregnancy Virology Internal medicine Prevalence Trichomonas vaginalis medicine Animals Humans Urethritis Vaginitis Trichomoniasis Nitroimidazole business.industry medicine.disease Tinidazole Metronidazole Infectious Diseases chemistry Nitroimidazoles Pregnancy Complications Parasitic Immunology Female Morbidity business medicine.drug |
| Zdroj: | Expert Review of Anti-infective Therapy. 4:125-135 |
| ISSN: | 1744-8336 1478-7210 |
| DOI: | 10.1586/14787210.4.1.125 |
| Popis: | Trichomonas vaginalis has long been recognized as a cause of infectious vaginitis in women. More recently, studies have demonstrated a significant burden of disease in men with urethritis or men at high risk for sexually transmitted diseases. There is increasing interest in this pathogen as more data accumulates linking it to HIV transmission and perinatal morbidity. New diagnostic methods have emerged that may increase sensitivity of diagnosis or improve point-of-care access to testing. Nitroimidazoles remain the mainstay of therapy. Metronidazole and tinidazole are highly effective as single-dose therapy. Unfortunately, despite the link between T. vaginalis infection and perinatal morbidity, nitroimidazole therapy during pregnancy remains controversial. Although metronidazole resistance is currently uncommon, pharmacological features and nitroimidazole resistance patterns suggest that tinidazole may be more effective in treating patients with metronidazole treatment failure. Alternatives to nitroimidazole therapy are few, and most have limited efficacy and significant toxicity. |
| Databáze: | OpenAIRE |
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