Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas
| Autor: | Woo-Youl Jang, Kyung-Hwa Lee, Min Wen, Kyung-Sub Moon, Jian Pei, Hyang-Hwa Ryu, Song-Yuan Li, Tae-Young Jung, Shin Jung, Shu-Guang Jin, In-Young Kim |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Hyperostosis Osteolysis Matrix metalloproteinase Meningioma Matrix Metalloproteinase 13 Biomarkers Tumor Matrix Metalloproteinase 14 Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Neoplasm Invasiveness In patient neoplasms business.industry Skull medicine.disease Matrix Metalloproteinases nervous system diseases Matrix Metalloproteinase 9 Matrix Metalloproteinase 2 Female Surgery Neurology (clinical) Neurosurgery business |
| Zdroj: | Acta Neurochirurgica. 154:611-620 |
| ISSN: | 0942-0940 0001-6268 |
| DOI: | 10.1007/s00701-012-1289-1 |
| Popis: | Although bone invasion and hyperostosis are common phenomena in patients with intracranial meningiomas, the basic pathomechanism is not fully understood. Based on an immunohistochemical study of surgically resected samples with hyperostosis, we postulate a possible mechanism of hyperostosis in patients with intracranial meningiomas.Forty-six meningiomas were evaluated in this study. Twenty-six meningiomas associated with hyperostosis specimens served as the study group, and 20 meningiomas without any bony changes served as controls. An immunohistochemical staining technique was used to detect the expression of matrix metalloproteinase (MMP)-2, -9, and -13, membrane type (MT)1-MMP, estrogen receptor (ER), and progesterone receptor (PR) in the main tumor and hyperostotic portions of the studied samples.In the non-hyperostosis group, expression of MMP-13, MT1-MMP, and ER was significantly less than in the main tumor portion of hyperostotic meningiomas, while there was no difference in the expression of MMP-2 and -9 and PR in the main tumor between the two groups. In the hyperostosis group, the immunoreactivity of MMP-2 in the hyperostotic portion revealed a higher pattern of expression than the main tumor (p0.002). The expression of MMP-9, MT1-MMP, ER, and PR had relatively positive immunoreactivity in the main tumor portion (P0.05).Increased expression of MMP-13 and MT1-MMP in the tumor portion of hyperostosis of meningiomas might contribute to the initiation of osteolysis. Activated MMP-2 in hyperostotic lesions may change the physiological metabolism of the skull bone, thus playing an important role in hyperostosis formation. |
| Databáze: | OpenAIRE |
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