Consumption of Galactooligosaccharides together with Probiotics Stimulates the In Vitro Peripheral Blood Mononuclear Cell Proliferation and IFNγ Production in Healthy Men
| Autor: | Riitta Korpela, Katja Hatakka, Tuija Poussa, Riina A. Kekkonen, Herman Adlercreutz, Outi Vaarala, Reetta Holma |
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| Rok vydání: | 2011 |
| Předmět: |
Bifidobacterium breve
Article Subject biology Propionibacterium freudenreichii ved/biology ved/biology.organism_classification_rank.species food and beverages Peripheral blood mononuclear cell proliferation biology.organism_classification Peripheral blood mononuclear cell In vitro Microbiology Lactobacillus rhamnosus Immunology |
| Zdroj: | University of Helsinki |
| ISSN: | 2090-5653 2090-5645 |
| Popis: | Probiotics and prebiotics modify the intestinal environment and could have immunomodulatory effects. The proliferation of spontaneous and phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) and their production of interleukin-4, interleukin-5, transforming growth factor-β1, and interferon-γ (IFNγ) were determined in eighteen men at the baseline and during a 2-week period of probiotics (mixture of Lactobacillus rhamnosus GG, Lactobacillus rhamnosus LC705, Propionibacterium freudenreichii ssp. shermanii JS, and Bifidobacterium breve Bb99) and galactooligosaccharides (GOSs) (3.8 g/day). The spontaneous and stimulated proliferation of PBMC increased from the baseline during probiotics+GOS (P<0.001). The secretion of IFNγ, but not other cytokines, by stimulated PBMC increased during the same period (P<0.05). In conclusion, the consumption of this probiotic mixture including GOS appears to increase the capacity of PBMC to proliferate and release IFNγ selectively in healthy men. |
| Databáze: | OpenAIRE |
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