Prospective associations between vitamin D status, vitamin D–related gene polymorphisms, and risk of tobacco-related cancers
Autor: | Nathalie Charnaux, Sigrid Le Clerc, Serge Hercberg, Pilar Galan, Jean-Claude Souberbielle, Nathalie Druesne-Pecollo, Mélanie Deschasaux, Emmanuelle Kesse-Guyot, Mathilde Touvier, Paule Latino-Martel, Angela Sutton, Khaled Ezzedine |
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Přispěvatelé: | Deschasaux-Tanguy, Mélanie, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), U845 Department of Physiology, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Avicenne [AP-HP], Laboratoire génomique, bioinformatique et applications (GBA), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Service de dermatologie Hôpital Saint-André Bordeaux, CHU Bordeaux [Bordeaux], French Research Institute for Public Health (grant AAR201206), Cancéropôle Ile-de-France (public funding from the Paris region), Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Hôpital Jean Verdier [Bondy], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital avicenne, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Avicenne, ProdInra, Migration, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Public Health Department, Dermatology Department, Habib Thameur Hospital, French Research Institute for Public Health (IRESP) [AAR201206], Cancéropôle Ile-de-France, Ile-de-France Region (PhD grant), Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Paris 13 (UP13)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée |
Jazyk: | angličtina |
Rok vydání: | 2015 |
Předmět: |
Male
Oncology Medicine (miscellaneous) Cohort Studies Tobacco Use chemistry.chemical_compound single nucleotide polymorphisms 25 hydroxyvitamin d Risk Factors Neoplasms 25-Hydroxyvitamin D 2 Prospective cohort study ComputingMilieux_MISCELLANEOUS Nutrition and Dietetics Middle Aged 3. Good health tobacco related cancers Female France Adult Vitamin medicine.medical_specialty Nutritional Status [SDV.CAN]Life Sciences [q-bio]/Cancer Polymorphism Single Nucleotide vitamin D deficiency Double-Blind Method [SDV.CAN] Life Sciences [q-bio]/Cancer Internal medicine medicine Vitamin D and neurology Humans Genetic Predisposition to Disease Genetic Association Studies Aged Calcifediol nested case control study Retinoid X Receptor alpha business.industry Case-control study Vitamin D Deficiency medicine.disease [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition chemistry [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Case-Control Studies Nested case-control study Receptors Calcitriol [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Follow-Up Studies smoking status |
Zdroj: | The American Journal of Clinical Nutrition The American Journal of Clinical Nutrition, 2015, 102 (5), pp.1207-1215. ⟨10.3945/ajcn.115.110510⟩ American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 2015, 102 (5), pp.1207-1215. ⟨10.3945/ajcn.115.110510⟩ IARC's 50th Anniversary IARC's 50th Anniversary, Jun 2016, Lyon, France., 518 p., 2016, IARC's 50th Anniversary "Cancer: Occurrence, Causes, Prevention". Abstracts IARC's 50th Anniversary, Jun 2016, Lyon, France. 518 p., 2016, IARC's 50th Anniversary "Cancer: Occurrence, Causes, Prevention". Abstracts |
ISSN: | 0002-9165 1938-3207 |
Popis: | International audience; Background: Experimental evidence has suggested that vitamin D may be protective against tobacco-related cancers through the inhibition of the formation of tumors induced by tobacco carcinogens. To our knowledge, only one previous epidemiologic study investigated the association between vitamin D status and tobacco-related cancer risk, and no study has focused on vitamin D related gene polymorphisms. Objective: Our objective was to prospectively study the association between plasma 25-hydroxyvitamin D [25(OH)D] concentrations, vitamin D related gene polymorphisms, and risk of tobacco-related cancers. Design: A total of 209 tobacco-related cancers were diagnosed within the SU.VI.MAX (Supplementation en vitamines et mineraux anti-oxydants) cohort (1994-2007) and were matched with 418 controls as part of a nested case-control study. Tobacco-related cancers (i.e., cancers for which tobacco is one of the risk factors) included several sites in the respiratory, digestive, reproductive, and urinary systems. Total plasma 25(OH)D was assessed with the use of an electrochemoluminescent assay. Polymorphisms were determined with the use of a Taq-Man assay. Conditional logistic regression models were computed. Results: A 25(OH)D concentration >= 30 ng/mL was associated with reduced risk of tobacco-related cancers (OR for 30 compared with = 30 ng/mL] was associated with decreased risk of tobacco-related cancers, especially in smokers. These results, which are supported by mechanistic plausibility, suggest that vitamin D may contribute to the prevention of tobacco-induced cancers in smokers and deserve additional investigation. |
Databáze: | OpenAIRE |
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