Paraquat and psychological stressor interactions as pertains to Parkinsonian co-morbidity
| Autor: | Shuaib Syed, Darcy Litteljohn, Zach Dwyer, Shawn Hayley, Chris Rudyk |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
TNF-α
tumour necrosis factor-alpha Anhedonia Physiology Striatum PD Parkinson's disease Biochemistry lcsh:RC346-429 chemistry.chemical_compound 0302 clinical medicine Endocrinology Paraquat IFN-γ interferon-γ Original Research Article 5-HT serotonin ANOVA analysis of variance CIS chronic intermittent immobilization/social defeat stressor 0303 health sciences Monoamine lcsh:QP351-495 MHPG 3-methoxy-4-hydroexyphenylglycol 3. Good health LC locus coeruleus Neuroendocrine Psychological stressor GM-CSF granulocyte-macrophage colony-stimulating factor Psychology MIP macrophage inflammatory protein medicine.medical_specialty LLOQ lower limit of quantification Context (language use) 5-HIAA 5-hydroxyindole acetic acid Nucleus accumbens lcsh:RC321-571 MCP monocyte chemoatrractant protein 03 medical and health sciences Cellular and Molecular Neuroscience Neurochemical Stressor Internal medicine medicine HVA homovanillic acid lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Cytokine Molecular Biology lcsh:Neurology. Diseases of the nervous system 030304 developmental biology KO knockout EDTA ethylenediaminetetraacetic acid Endocrine and Autonomic Systems DOPAC 3 4-Dihydroxyphenylacetic acid IL interleukin Pesticide lcsh:Neurophysiology and neuropsychology chemistry HPLC high-performance liquid chromatography Locus coeruleus DA dopamine NE norepinephrine 030217 neurology & neurosurgery PVN paraventricular nucleus |
| Zdroj: | Neurobiology of Stress Neurobiology of Stress, Vol 2, Iss C, Pp 85-93 (2015) |
| ISSN: | 2352-2895 |
| DOI: | 10.1016/j.ynstr.2015.09.001 |
| Popis: | A number of epidemiological and experimental studies have implicated the non-selective herbicide, paraquat, in the development of sporadic Parkinson's disease (PD). While preclinical research has focused mainly on elucidating the nigrostriatal effects of paraquat, relatively little data are available concerning non-motor brain systems and inflammatory immune processes (which have been implicated in PD). Hence, in the present study, we sought to take a multi-system approach to characterize the influence of paraquat upon extra-nigrostriatal brain regions, as well ascertain whether the impact of the pesticide might be enhanced in the context of chronic intermittent stressor exposure. Our findings support the contention that paraquat itself acted as a systemic stressor, with the pesticide increasing plasma corticosterone, as well as altering neurochemical activity in the locus coeruleus, paraventricular nucleus of the hypothalamus, nucleus accumbens, dorsal striatum, and central amygdala. However, with the important exception striatal dopamine turnover, the stressor treatment did not further augment these effects. Additionally, paraquat altered inter-cytokine correlations and, to a lesser extent, circulating cytokine levels, and concomitant stress exposure modulated some of these effects. Finally, paraquat provoked significant (albeit modest) reductions of sucrose preference and weight gain, hinting at possible anhendonic-like or sickness responses. These data suggest that, in addition to being a well known oxidative stress generator, paraquat can act as a systemic stressor affecting hormonal and neurochemical activity, but largely not interacting with a concomitant stressor regimen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|