Effect of postoperative radiation therapy on mandibular reconstruction using a modular endoprosthesis – A pilot study

Autor: Kok Weng Lye, Henk Tideman, John A. Jansen, Matthias A.W. Merkx, Francis Kuok Choon Chin
Rok vydání: 2013
Předmět:
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Brachytherapy
Dentistry
Biocompatible Materials
Pilot Projects
Mandible
Prosthesis Design
Prosthesis
Imaging
Three-Dimensional
Surgical Wound Dehiscence
Alloys
medicine
Animals
Mandibular reconstruction
Radiation Injuries
Oral Ulcer
Postoperative Care
Titanium
Stomatitis
business.industry
Wound dehiscence
Postoperative radiation
Bone Cements
Mouth Mucosa
Soft tissue
X-Ray Microtomography
Cone-Beam Computed Tomography
Evaluation of complex medical interventions Translational research [NCEBP 2]
Tissue engineering and pathology [NCMLS 3]
medicine.disease
Internal Fixators
Prosthesis Failure
Surgery
Radiation therapy
Macaca fascicularis
Otorhinolaryngology
Radiotherapy
Adjuvant
Mandibular Reconstruction
Oral Surgery
business
Oral Fistula
Bone volume
Zdroj: Journal of Cranio-Maxillo-Facial Surgery, 41, 6, pp. 487-95
Journal of Cranio-Maxillo-Facial Surgery, 41, 487-95
ISSN: 1010-5182
DOI: 10.1016/j.jcms.2012.11.014
Popis: Item does not contain fulltext The endoprosthetic system has been shown to be a potential option for mandibular reconstruction. The objective of this pilot in vivo animal study was to determine the effects of postoperative radiation using brachytherapy on bone and soft tissue healing in mandibles reconstructed with the endoprosthesis. Six adult Macaca fascicularis mandibles were reconstructed with a cemented endoprosthesis after segmental body resection. The animals were divided into two groups. The test group was subjected to radiation therapy 1 month postoperation while the control group did not receive any radiation. Results showed no major radiation side effects. Mucosal ulcerations and wound dehiscence at the radiated sites healed within 4 weeks. One animal from each group had prosthesis failure and was unable to complete the study. Micro-CT findings indicated no significant differences between the total bone volume percentage (TBV%) of the study and control groups. Histomorphometrical analysis using grading scales also showed no significant differences between the two groups. Under the study conditions, postoperative brachytherapy did not affect the tissue response around the endoprosthesis within the early 6 months postradiation period. The endoprosthesis, therefore, remains a viable reconstructive option when postoperative radiation is prescribed.
Databáze: OpenAIRE
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