Rapid hydrogenation of unsaturated sterols and bile alcohols using microwaves
| Autor: | Gerald Salen, A. Asgaonkar, B. Dayal, K.R. Rapole, Norman H. Ertel |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Campesterol
Clinical Biochemistry Biochemistry Cerebrotendinous Xanthomatosis Chloride Catalysis chemistry.chemical_compound Endocrinology polycyclic compounds Ammonium formate medicine Organic chemistry Methylene Microwaves Molecular Biology Pharmacology Organic Chemistry medicine.disease Sterol Sterols chemistry lipids (amino acids peptides and proteins) Hydrogenation Sitosterolemia Cholestanols medicine.drug |
| Zdroj: | Steroids. 62(5) |
| ISSN: | 0039-128X |
| Popis: | This paper describes an operationally simple, rapid hydrogenation of unsaturated sterols and bile alcohols in a domestic microwave oven. This has been achieved by the addition of catalytic amounts of Pd C in methylene chloride/propylene glycol solvents in the presence of ammonium formate followed by microwave irradiation. It is suggested that this methodology will be helpful in the identification of saturated and unsaturated sterols with different side-chain structures in rare diseases: sitosterolemia, cerebrotendinous xanthomatosis (CTX), as well as atherosclerosis and diabetes mellitus. Sterols, such as cholesterol, campesterol, sitosterol, and bile alcohols with unsaturated side chains, were converted to their reduced congeners with high yield and purity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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