Staphylococcal Small Colony Variants Have Novel Mechanisms for Antibiotic Resistance
Autor: | C. von Eiff, Richard A. Proctor, Barbara C. Kahl, Daniel Pablo Lew, Pierre Vaudaux, Georg Peters |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Microbiology (medical)
Staphylococcus aureus medicine.drug_class Population Antibiotics Colony Count Microbial Drug resistance Biology medicine.disease_cause Microbiology Electron Transport Antibiotic resistance Biopolymers medicine Animals Humans Staphylococcal Infections/drug therapy/microbiology education Antibacterial agent ddc:616 Spores Bacterial education.field_of_study Staphylococcus aureus/ drug effects/physiology Drug Resistance Microbial Staphylococcal Infections Antimicrobial Infectious Diseases Laboratories Staphylococcus |
Zdroj: | Clinical Infectious Diseases, Vol. 27, No Suppl 1 (1998) pp. S68-74 |
ISSN: | 1058-4838 |
Popis: | Over the past 4 years, a variant subpopulation of Staphylococcus aureus has been characterized that is defective in electron transport. These organisms grow slowly and are typical of the previously described small colony variants (SCVs). Indeed, many earlier papers included data that are consistent with defective respiratory activity in SCVs. We present a hypothesis that serves as biochemical basis for the development of SCVs. These variants are particularly interesting because they have been associated with very persistent infections, and they are more resistant to many antibiotics than normal S. aureus. Because of their slow growth, atypical colonial morphology, and unusual biochemical profile, they are easily missed or misidentified in the clinical laboratory. This is of some significance, as this subpopulation is more resistant to antibiotics than the parent population from which they arose. When an infection is particularly resistant to therapy, persists for a long period, or fails to respond to apparently adequate antimicrobial therapy, clinicians and clinical laboratory personnel should consider special efforts to search for SCVs. |
Databáze: | OpenAIRE |
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