Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling
| Autor: | Yujung Michelle Lee, Mathias Leblanc, Brett Collins, Janelle S. Ayres, Michael Downes, Alexandria M. Palaferri Schieber, Max W. Chang, Ronald M. Evans |
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| Rok vydání: | 2015 |
| Předmět: |
Salmonella typhimurium
Burkholderia Inflammasomes Inflammation Biology Microbiology Mice NLRC4 medicine Escherichia coli Animals Microbiome Wasting Syndrome Insulin-Like Growth Factor I Muscle Skeletal Wasting PI3K/AKT/mTOR pathway Multidisciplinary Microbiota Calcium-Binding Proteins Skeletal muscle Inflammasome Burkholderia Infections Biosynthetic Pathways Intestines Mice Inbred C57BL medicine.anatomical_structure Immunology Salmonella Infections medicine.symptom Phosphatidylinositol 3-Kinase Apoptosis Regulatory Proteins Proto-Oncogene Proteins c-akt medicine.drug |
| Zdroj: | Science (New York, N.Y.). 350(6260) |
| ISSN: | 1095-9203 |
| Popis: | The benefits of Escherichia coli Infection and intestinal damage can trigger severe muscle wasting and loss of fat in mice. How this happens is poorly understood. Palaferri Schieber et al. discovered a protective Escherichia coli strain in their mouse colony. Mice intestinally colonized with the E. coli and infected with the food-poisoning bug Salmonella or with the lung pathogen Burkholderia did not waste away. Without the E. coli , similarly infected mice became fatally ill. The protective E. coli stimulated an innate immune mechanism that ensured that muscle-signaling pathways were not damaged by infection. Thus, the friendly E. coli allowed its host to tolerate and survive the pathogens. Science , this issue p. 558 |
| Databáze: | OpenAIRE |
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