An evaluation of the efficacy of vasoactive intestinal polypeptide antagonists in vivo in the anaesthetized dog
| Autor: | B.A. Hennessy, F. Markos, M. Fitzpatrick, John F. O'Sullivan, H. M. Snow |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
chemistry.chemical_classification medicine.medical_specialty Chemistry Vasoactive intestinal peptide Antagonist Peptide General Medicine Pituitary adenylate cyclase-activating peptide Endocrinology Dogs In vivo Heart Rate Internal medicine Heart rate medicine Animals Receptors Vasoactive Intestinal Peptide Receptor hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pharmacology. 66(4) |
| ISSN: | 0031-7012 |
| Popis: | The effectiveness of competitive peptide vasoactive intestinal polypeptide (VIP) receptor antagonists was evaluated on heart rate in the anaesthetized dog. Two specific antagonists, VIP (6–28) and [D-p-Cl-Phe6, Leu17]-VIP, and a nonspecific antagonist, pituitary adenylate cyclase activating peptide fragment (6–27) (PACAP), were studied. VIP (6–28) and [D-p-Cl-Phe6, Leu17]-VIP (100 µg i.c.) increased the heart rate, whereas PACAP (100 µg i.c.) reduced the baseline heart rate. All three shifted the VIP dose-response curve to the right by two- to threefold for 30 min. In conclusion, PACAP, VIP (6–28), and [D-p-Cl-Phe6, Leu17]-VIP have a direct effect on the heart rate, are equally effective, and the effects last approximately 30 min in vivo. |
| Databáze: | OpenAIRE |
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