Physical Inactivity, Obesity, and Type 2 Diabetes: An Evolutionary Perspective
| Autor: | S B Eaton, S. Boyd Eaton |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Blood Glucose medicine.medical_specialty medicine.medical_treatment Glucose uptake Blood sugar 030209 endocrinology & metabolism Physical Therapy Sports Therapy and Rehabilitation Type 2 diabetes 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Hyperinsulinism medicine Hyperinsulinemia Adipocytes Animals Humans Orthopedics and Sports Medicine Obesity Exercise Muscle Cells biology business.industry Insulin General Medicine medicine.disease Receptor Insulin Insulin receptor 030104 developmental biology Endocrinology Adipose Tissue Diabetes Mellitus Type 2 Nephrology biology.protein Body Composition Insulin Resistance Sedentary Behavior business |
| Zdroj: | Research quarterly for exercise and sport. 88(1) |
| ISSN: | 2168-3824 |
| Popis: | Physical inactivity (and unhealthy nutrition) has distorted body composition and, in turn, reordered the proportions of myocyte and adipocyte insulin receptors. Insulin acting on adipocyte receptors produces less glucose uptake than does comparable interaction with myocyte receptors. Accordingly, in individuals with disproportionate muscle/fat composition, any given glucose load requires greater-than-normal pancreatic insulin secretion for adequate disposal. This hyperinsulinemia then becomes the leading cause of type 2 diabetes (T2DM) as insulin-sensitive tissues become desensitized. Because T2DM is rooted in potentially reversible lifestyle factors, rather than focusing on the intricacies of glucoregulation at the molecular level and on testing new drugs to control blood sugar, this article calls for a new prevention and treatment paradigm, in which exercise and weight control are essential and for which an inexpensive and acceptably accurate measure of body muscle and fat proportions is needed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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