MCR under Microwave Irradiation: Synthesis in Water of New 2-Amino-bis(2-phosphonoacetic) Acids
| Autor: | Bernard Moreau, Didier Villemin, Nathalie Bar |
|---|---|
| Přispěvatelé: | Laboratoire de chimie moléculaire et thioorganique (LCMT), Centre National de la Recherche Scientifique (CNRS)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Steric effects Primary (chemistry) green conditions 010405 organic chemistry aminophosphonic acetic acid [CHIM.ORGA]Chemical Sciences/Organic chemistry Tryptophan Organic chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Amino acid chemistry.chemical_compound QD241-441 chemistry Microwave irradiation multicomponent reaction (MCR) Amine gas treating Phosphorous acid microwave irradiation Glyoxylic acid |
| Zdroj: | Organics Organics, MDPI, 2021, 2 (2), pp.98-106. ⟨10.3390/org2020009⟩ Organics, Vol 2, Iss 9, Pp 98-106 (2021) Volume 2 Issue 2 Pages 9-106 |
| ISSN: | 2673-401X |
| DOI: | 10.3390/org2020009⟩ |
| Popis: | International audience; Novel 2-amino bis(2-phosphonoacetic) acids were prepared by microwave irradiation of a mixture of amine, glyoxylic acid and phosphorous acid. The reaction takes place with various amines including primary and secondary amines and polyamines, but this reaction is more sensitive to steric hindrance of amine than the similar Kabachnik–Fields reaction. Amino acids can be also transformed into the expected bis(2-phosphonoacetic) acids, with the exception of tryptophan, which gives a β-carboline product. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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