Experimental Bi-axial tensile tests of spinal meningeal tissues and constitutive models comparison

Autor: Yannick Tillier, Pierre-Jean Arnoux, Yves Godio-Raboutet, Éric Wagnac, Patrice Sudres, Morgane Evin, Pascal Weber, Yvan Petit
Přispěvatelé: Centre de Mise en Forme des Matériaux (CEMEF), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Mines Paris - PSL (École nationale supérieure des mines de Paris), Laboratoire de Biomécanique Appliquée (LBA UMR T24), Aix Marseille Université (AMU)-Université Gustave Eiffel
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Materials science
Swine
0206 medical engineering
Population
Constitutive equation
Biomedical Engineering
Context (language use)
02 engineering and technology
Biochemistry
[SPI.MAT]Engineering Sciences [physics]/Materials
Biomaterials
03 medical and health sciences
0302 clinical medicine
Elastic Modulus
Tensile Strength
medicine
Animals
Composite material
education
[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Molecular Biology
Elastic modulus
ComputingMilieux_MISCELLANEOUS
education.field_of_study
Pia mater
Linear elasticity
Isotropy
Biaxial tensile test
[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph]
General Medicine
020601 biomedical engineering
[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation
Biomechanical Phenomena
medicine.anatomical_structure
Anisotropy
Pia Mater
Stress
Mechanical
Arachnoid
030217 neurology & neurosurgery
Biotechnology
Zdroj: Acta Biomaterialia
Acta Biomaterialia, Elsevier, 2021, ⟨10.1016/j.actbio.2021.11.028⟩
Acta Biomaterialia, 2021, ⟨10.1016/j.actbio.2021.11.028⟩
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2021.11.028⟩
Popis: Introduction This study aims at identifying mechanical characteristics under bi-axial loading conditions of extracted swine pia mater (PM) and dura and arachnoid complex (DAC). Methods 59 porcine spinal samples have been tested on a bi-axial experimental device with a pre-load of 0.01 N and a displacement rate of 0.05 mm.s−1. Post-processing analysis included an elastic modulus, as well as constitutive model identification for Ogden model, reduced Gasser Ogden Holzapfel (GOH) model, anisotropic GOH model, transverse isotropic and anisotropic Gasser models as well as a Mooney-Rivlin model including fiber strengthening for PM. Additionally, micro-structure of the tissue was investigated using a bi-photon microscopy. Results Linear elastic moduli of 108±40 MPa were found for DAC longitudinal direction, 53±32 MPa for DAC circumferential direction, with a significant difference between directions (p Statement of Significance This study is the first to present biaxial tensile test of pia mater as well as constitutive model comparisons for dura and arachnoid complex tissue based on such tests. Collagen structures observed by semi-quantitative analysis of two photon microscopy confirmed the use of anisotropic Gasser model for pia mater and existence of fenestration. While clear identification of fibre population was not possible in DAC, results from anisotropic Gasser model depicted better fitting on experimental data as per this protocol. Bi-axial mechanical testing allows quasi-static characterization under conditions closr to the physiological context and the results presented could be used for further simulations of physiology. Indeed, the inclusion of meningeal tissue in finite element models will allow more accurate and reliable numerical simulations.
Databáze: OpenAIRE
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