Clinical characteristics and prognosis of familial nonmedullary thyroid carcinoma

Autor: Joaquín, de Carlos Artajo, Ana, Irigaray Echarri, Javier, García Torres, José Javier, Pineda Arribas, Ander, Ernaga Lorea, Nerea, Eguílaz Esparza, Juan Manuel, Zubiría Gortázar, Emma, Anda Apiñániz
Rok vydání: 2022
Předmět:
Zdroj: Endocrinología, Diabetes y Nutrición (English ed.). 69:262-270
ISSN: 2530-0180
1990-2018
DOI: 10.1016/j.endien.2022.03.003
Popis: Familial non-medullary thyroid carcinoma (FNMTC) is defined by the presence of 2 or more first-degree family members with differentiated thyroid carcinoma (DTC). The aim of this study is to compare clinicopathological features and prognosis of FNMTC and sporadic carcinoma (SC).Retrospective study of DTC included in the hospital database during the period 1990-2018.A total of 927 patients were analyzed, 61 of them were FNMTC, with a mean follow-up of 9.7 ± 6.5 years. The prevalence of FNMTC was 6.6%, with a lower TNM staging presentation (P = 0.003) consequence of a higher proportion of tumors smaller than 2 cm (P = 0.003), combined with a greater multifocality (P = 0.034) and papillary histologic subtype (P = 0.022) compared to SC. No significant differences in age at diagnosis (P = 0.347), gender (P = 0.406), neither in other aggressiveness markers (bilaterality, extrathyroidal extension, lymph node involvement and metástasis) were detected. Rate of persistence/recurrence (P = 0.656), disease-free survival (P = 0.929) and mortality caused by the tumor itself (P = 0.666) were comparable. Families with ≥3 affected relatives, had smaller tumors (P = 0.005), more multifocality (P = 0.040) and bilaterality (P = 0.002), as well as a higher proportion of males (P = 0.020). Second generation patients present earlier FNMTC compared to those of the first generation (P = 0.001).In our study FNMTC presents a lower TNM staging, higher multifocality and papillary variant, with similar aggressiveness and prognosis compared to SC.
Databáze: OpenAIRE
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