Status epilepticus: Practice variation and adherence to treatment guideline in a large community hospital
| Autor: | Reetta Kälviäinen, Joni J. Sairanen, Harri T. Hyppölä, Anne-Mari Kantanen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Hospitals Community Status epilepticus Loading dose 03 medical and health sciences Benzodiazepines 0302 clinical medicine Pharmacotherapy Status Epilepticus Seizures Intensive care Medicine Humans 030212 general & internal medicine Dosing Child business.industry Emergency department Guideline Community hospital Neurology Anticonvulsants Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of the neurological sciences. 427 |
| ISSN: | 1878-5883 |
| Popis: | PURPOSE To evaluate the treatment of status epilepticus (SE) and adherence to treatment guideline in a large Finnish community hospital. MATERIALS AND METHODS A consecutive series of 137 patients treated in the emergency department of Kuopio University Hospital. Enrollment took place between March 23 and December 31, 2015. Pediatric patients and postanoxic seizures were excluded. The Finnish Status Epilepticus Current Care Guideline was used as the evaluation benchmark. RESULTS Seventeen patients recovered spontaneously. First-line treatment was given to 108 patients with 35.2% efficacy. Second-line treatment was given to 81 patients with 87.7% efficacy. Six patients with refractory SE received successful third-line treatment and four were excluded from intensive care because of futility. The starting dose of a first-line drug was lower than the lowest therapeutic dose in 37.0% of the patients. The escalation from first- to second-line treatment took longer than 60 min in 55.1% of the 70 patients who received both treatments. The first loading dose of a second-line drug was markedly low ( |
| Databáze: | OpenAIRE |
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