Physiological parameters of Macaca fascicularis immunized with anti-rubella vaccine with germanium-based adjuvants
| Autor: | I. N. Lavrent’eva, D. D. Karal-ogly, Yu. P. Chuguev, I. A. Gvaramiya, E. I. Mukhametzyanova, S. K. Matelo, I. V. Ambrosov, V. Z. Agrba, T. E. Gvozdik |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_treatment Drug Evaluation Preclinical medicine.disease_cause Immunoglobulin E Antibodies Viral Vaccines Attenuated Rubella General Biochemistry Genetics and Molecular Biology Rubella vaccine Rubella virus vaccine Adjuvants Immunologic medicine Organometallic Compounds Animals Rubella Vaccine biology business.industry Germanium virus diseases Rubella virus General Medicine medicine.disease Virology Blood Cell Count Rats Macaca fascicularis Immunization Immunology Toxicity biology.protein Female business Adjuvant medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 157(1) |
| ISSN: | 1573-8221 |
| Popis: | Clinical status, hematological and biochemical parameters, and allergenic activity of organogermanium compounds used as adjuvants in complex with preparation from Orlov rubella virus vaccine strain and reference commercial anti-rubella vaccine based on Wistar RA 27/3 strain were studied on Macaca fascilcularis of both genders. Physiological parameters of monkeys immunized with the Russian and foreign rubella virus vaccine strains with and without adjuvants did not differ. The adjuvants were inessential for the safety of vaccines (absence of toxicity, reactogenic activity, or allergenic activity) in preclinical studies on lower primates. |
| Databáze: | OpenAIRE |
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