Retinoids Inhibit Primary Cynomolgus Monkey Hepatocyte Lipoprotein(a) Levels
| Autor: | Catherine S. Sekerke, Mark A. Spahr, Randy Ramharack |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Biophysics Retinoic acid Biochemistry Retinoids chemistry.chemical_compound Internal medicine medicine Animals RNA Messenger Molecular Biology Apolipoproteins A Cells Cultured Messenger RNA Dose-Response Relationship Drug biology Retinol Retinal Cell Biology Lipoprotein(a) Macaca fascicularis medicine.anatomical_structure Endocrinology Liver chemistry Low-density lipoprotein Hepatocyte biology.protein lipids (amino acids peptides and proteins) |
| Zdroj: | Biochemical and Biophysical Research Communications. 238:48-52 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1997.7240 |
| Popis: | Elevated plasma lipoprotein(a) [Lp(a)] independently contributes to a variety of vascular diseases; consequentially, factors that modulate its levels are of interest. Since Lp(a) is produced by a disulfide linkage between apolipoprotein(a) [apo(a)] and apolipoproteinB-100 (apoB-100) of low density lipoprotein (LDL) on the hepatocyte surface, modulation of either particle may be useful in lowering Lp(a). Using primary cynomolgus monkey hepatocyte cultures that endogenously express apo(a) and apoB-100, we showed that all- trans (retinol, retinal, retinoic acid) and 9- cis (retinal, retinoic acid) retinoids lower Lp(a) accumulation in the cell media, with the 9- cis derivatives being >10-fold more potent than the all- trans stereoisomers. Lp(a) lowering was related to decreases in apo(a) and its cognate transcript, but not to apoB-100. These results demonstrate that retinoids lower Lp(a) levels by decreasing apo(a) through its cognate mRNA. |
| Databáze: | OpenAIRE |
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