Mechanisms Underlying the Anti-Suicidal Treatment Potential of Buprenorphine
| Autor: | Courtney M. Cameron, Steven J. Nieto, Larissa Mooney, Megan Wong, Lucienne Bosler, Isabel Bishop, Catherine M. Cahill |
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| Rok vydání: | 2022 |
| Předmět: |
Suicide Prevention
medicine.medical_specialty medicine.drug_class kappa opioid κ-opioid receptor Substance Misuse 03 medical and health sciences 0302 clinical medicine Clinical Research Behavioral and Social Science medicine 2.1 Biological and endogenous factors pain Aetiology Psychiatry Suicidal ideation dysphoria Depression (differential diagnoses) Depression business.industry Prevention Pain Research Neurosciences Chronic pain opioid use disorder Opioid use disorder medicine.disease Brain Disorders 030227 psychiatry suicidal ideation anhedonia Suicide Mental Health Good Health and Well Being Opioid addiction Chronic Pain medicine.symptom business 030217 neurology & neurosurgery Opioid antagonist Buprenorphine medicine.drug |
| Zdroj: | Advances in drug and alcohol research. 1 |
| ISSN: | 2674-0001 |
| Popis: | Death by suicide is a global epidemic with over 800 K suicidal deaths worlwide in 2012. Suicide is the 10th leading cause of death among Americans and more than 44 K people died by suicide in 2019 in the United States. Patients with chronic pain, including, but not limited to, those with substance use disorders, are particularly vulnerable. Chronic pain patients have twice the risk of death by suicide compared to those without pain, and 50% of chronic pain patients report that they have considered suicide at some point due to their pain. The kappa opioid system is implicated in negative mood states including dysphoria, depression, and anxiety, and recent evidence shows that chronic pain increases the function of this system in limbic brain regions important for affect and motivation. Additionally, dynorphin, the endogenous ligand that activates the kappa opioid receptor is increased in the caudate putamen of human suicide victims. A potential treatment for reducing suicidal ideation and suicidal attempts is buprenorphine. Buprenorphine, a partial mu opioid agonist with kappa opioid antagonist properties, reduced suicidal ideation in chronic pain patients with and without an opioid use disorder. This review will highlight the clinical and preclinical evidence to support the use of buprenorphine in mitigating pain-induced negative affective states and suicidal thoughts, where these effects are at least partially mediated via its kappa antagonist properties. |
| Databáze: | OpenAIRE |
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