Is dengue and malaria co-infection more severe than single infections? A retrospective matched-pair study in French Guiana

Autor: Félix Djossou, S. Ouar-Epelboin, Philippe Dussart, Bernard Carme, Matthieu Hanf, Mathieu Nacher, Loïc Epelboin
Přispěvatelé: Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Service des maladies infectieuses et tropicales [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de Maladies Infectieuses et Tropicales [CHU Pitié-Salpêtrière], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424
Rok vydání: 2012
Předmět:
Adult
Male
Thrombocytopaenia
Pediatrics
medicine.medical_specialty
lcsh:Arctic medicine. Tropical medicine
Adolescent
lcsh:RC955-962
Matched-Pair Analysis
030231 tropical medicine
lcsh:Infectious and parasitic diseases
Dengue fever
Dengue
03 medical and health sciences
Young Adult
0302 clinical medicine
parasitic diseases
Medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Child
Aged
Retrospective Studies
business.industry
Coinfection
Research
Case-control study
Infant
Retrospective cohort study
Emergency department
Middle Aged
medicine.disease
3. Good health
French Guiana
Malaria
Case–control studies
Infectious Diseases
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Concomitant
Child
Preschool
Tropical medicine
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Parasitology
Female
business
Zdroj: Malaria Journal
Malaria Journal, BioMed Central, 2012, 11 (1), pp.142. ⟨10.3201/eid1305.060955⟩
Malaria Journal, Vol 11, Iss 1, p 142 (2012)
ISSN: 1475-2875
DOI: 10.3201/eid1305.060955⟩
Popis: Dengue and malaria are two major arthropod-borne infections in tropical areas, but dual infections were only described for the first time in 2005. Reports of these concomitant infections are scarce and there is no evidence of more severe clinical and biological pictures than single infections.
To compare co-infections to dengue alone and malaria alone, a retrospective matched-pair study was conducted between 2004 and 2010 among patients admitted in the emergency department of Cayenne hospital, French Guiana.
104 dengue and malaria co-infection cases were identified during the study period and 208 individuals were matched in two comparison groups: dengue alone and malaria alone. In bivariate analysis, co-infection clinical picture was more severe than separated infections, in particular using the severe malaria WHO criteria. In multivariate analysis, independent factors associated with co-infection versus dengue were: masculine gender, CRP level > 50 mg/L, thrombocytopaenia < 50 109/L, and low haematocrit
In the present study, dengue and malaria co-infection clinical picture seems to be more severe than single infections in French Guiana, with a greater risk of deep thrombocytopaenia and anaemia.
Databáze: OpenAIRE
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