Early treatment improves outcomes in acute hepatitis C virus infection: a meta-analysis
| Autor: | Raymond T. Chung, Kathleen E. Corey, Emmanuel C. Gorospe, J. Mendez-Navarro, Hui Zheng |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Disease Gastroenterology Antiviral Agents Virus Article Pharmacotherapy Virology Internal medicine Medicine Humans Aged Hepatology business.industry Hepatitis C Middle Aged medicine.disease Infectious Diseases Treatment Outcome Meta-analysis Immunology Female Acute hepatitis C business Viral load Clearance rate |
| Zdroj: | Journal of viral hepatitis. 17(3) |
| ISSN: | 1365-2893 |
| Popis: | Acute hepatitis C virus infection is associated with high rates of spontaneous clearance and variable rates of treatment-induced clearance. The benefit of early treatment versus awaiting spontaneous clearance is unknown, as is the optimal timing of treatment.We performed a MEDLINE and EMBASE search for the time period 1950 to October 2008. All English language abstracts using the search terms acute hepatitis C, hepatitis C and acute and hepatitis C and acute disease or acute infection were reviewed. Bibliographies were reviewed.Twenty-two studies including 1075 patients met the inclusion criteria. The sustained virologic response (SVR) rate for treated patients was 78%, significantly higher than 55.1% in untreated patients (OR = 3.08, 95% CI: 1.8-4.8 P value |
| Databáze: | OpenAIRE |
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