Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits

Autor: Béatrice Riteau, Martine Jandrot-Perrus, Vuong Ba Lê, Bruno Lina, Fatma Berri
Přispěvatelé: Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Rok vydání: 2013
Předmět:
[SDV]Life Sciences [q-bio]
HLA-G
Viral Nonstructural Proteins
RIG-I
NATURAL-KILLER-CELLS
0302 clinical medicine
Pandemic
Bystander effect
Respiratory system
Immunologic Surveillance
0303 health sciences
Fibrinolysis
PAR1
3. Good health
Innate immune sensors
INNATE IMMUNE-RESPONSE
Immunosurveillance
VIRUS NS1 PROTEIN
Molecular Medicine
medicine.symptom
PLASMINOGEN DEFICIENCY
Inflammation
Biology
Virus
ACUTE LUNG INJURY
03 medical and health sciences
Cellular and Molecular Neuroscience
Viral Proteins
A VIRUS
Influenza
Human
medicine
Humans
Receptor
PAR-1
Molecular Biology
030304 developmental biology
Pharmacology
HLA-G Antigens
Hemostasis
Innate immune system
Models
Immunological
Outbreak
CYTOTOXIC T-LYMPHOCYTES
Plasminogen
Cell Biology
Virology
ENDOTHELIAL-CELLS
Immunity
Innate
HLA-G EXPRESSION
Immunology
Influenza virus
030215 immunology
Zdroj: Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences, Springer Verlag, 2014, 71 (5), pp.885-898. ⟨10.1007/s00018-013-1479-x⟩
ISSN: 1420-9071
1420-682X
DOI: 10.1007/s00018-013-1479-x⟩
Popis: International audience; Influenza viruses cause acute respiratory infections, which are highly contagious and occur as seasonal epidemic and sporadic pandemic outbreaks. Innate immune response is activated shortly after infection with influenza A viruses (IAV), affording effective protection of the host. However, this response should be tightly regulated, as insufficient inflammation may result in virus escape from immunosurveillance. In contrast, excessive inflammation may result in bystander lung tissue damage, loss of respiratory capacity, and deterioration of the clinical outcome of IAV infections. In this review, we give a comprehensive overview of the innate immune response to IAV infection and summarize the most important findings on how the host can inappropriately respond to influenza.
Databáze: OpenAIRE
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