Cytoplasmic CD24 expression is a novel prognostic factor in diffuse-type gastric adenocarcinoma
| Autor: | Yuh-Yu Chou, Ray-Hwang Yuan, Po-Lin Lai, Fu-Chang Hu, Hsin-Lien Kao, Rey-Heng Hu, Yung-Ming Jeng, Tan-Tsao Lee, Wei-Chou Lin |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cytoplasm Lymphovascular invasion Cell Adenocarcinoma Immunoenzyme Techniques Serous Membrane Surgical oncology Stomach Neoplasms Biomarkers Tumor Medicine Humans Neoplasm Invasiveness skin and connective tissue diseases Aged Neoplasm Staging Aged 80 and over business.industry CD24 Mucin Stomach CD24 Antigen Adhesion Middle Aged Ligand (biochemistry) Prognosis Survival Analysis medicine.anatomical_structure Oncology Lymphatic Metastasis Surgery Female Lymph Nodes business |
| Zdroj: | Annals of surgical oncology. 14(10) |
| ISSN: | 1068-9265 |
| Popis: | CD24, a mucin like cell surface adhesion molecule and a ligand for P-selectin, has been reported as a prognostic factor in a variety of human cancers. However, the role of CD24 in gastric adenocarcinoma remains largely unknown.The expression pattern of CD24 in 103 gastric adenocarcinomas (31 diffuse type, 60 intestinal type, and 12 mixed type) was analyzed by immunohistochemistry.Cytoplasmic CD24 expression occurred in 50% of the gastric adenocarcinoma patients and was associated with high-stage tumor (Stage III-IV, P = .023), serosal invasion (SI, P = .010), lymphovascular invasion (LVI, P = .039), and lower 10-year survival (P = .0238). The CD24 staining pattern was different in intestinal and diffuse-type gastric adenocarcinomas. However, the tumor thrombi in lymphovascular spaces exhibited strong cytoplasmic CD24 expression in both types. Further analysis showed that cytoplasmic CD24 expression was, in fact, correlated with high-stage tumor, SI, LVI, and lower 10-year survival significantly (P = .020, P = .007, P = .018, P = .0285, respectively) in diffuse-type gastric adenocarcinoma. Moreover, multivariate analysis showed that cytoplasmic CD24 expression was an independent risk factor of SI and LVI respectively (P = .0083 and P = .0019), and thus it contributed to high-stage tumor and poor patient survival in diffuse- or mixed-type gastric adenocarcinoma.Cytoplasmic expression of CD24 was associated with invasiveness and poorer prognosis and can serve as a novel target for prognostic prediction and adjuvant treatment of patients with diffuse-type gastric adenocarcinoma after tumor resection. |
| Databáze: | OpenAIRE |
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