Aptamer base: a collaborative knowledge base to describe aptamers and SELEX experiments
| Autor: | Amanda Giamberardino, Erin M. McConnell, Maria C. DeRosa, Xueru Zhang, Jose Cruz-Toledo, Maureen McKeague, Michel Dumontier, Tariq Francis |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Databases
Factual Aptamer Computational biology Biology Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Molecular recognition 030304 developmental biology 0303 health sciences Collaborative knowledge SELEX Aptamer Technique Area of interest Original Articles Aptamers Nucleotide Base (topology) Research Design 030220 oncology & carcinogenesis Database Management Systems Experimental methods General Agricultural and Biological Sciences Systematic evolution of ligands by exponential enrichment Aptamers Peptide Information Systems |
| Zdroj: | Database-The Journal of Biological Databases and Curation. Oxford University Press Database: The Journal of Biological Databases and Curation |
| ISSN: | 1758-0463 |
| Popis: | Over the past several decades, rapid developments in both molecular and information technology have collectively increased our ability to understand molecular recognition. One emerging area of interest in molecular recognition research includes the isolation of aptamers. Aptamers are single-stranded nucleic acid or amino acid polymers that recognize and bind to targets with high affinity and selectivity. While research has focused on collecting aptamers and their interactions, most of the information regarding experimental methods remains in the unstructured and textual format of peer reviewed publications. To address this, we present the Aptamer Base, a database that provides detailed, structured information about the experimental conditions under which aptamers were selected and their binding affinity quantified. The open collaborative nature of the Aptamer Base provides the community with a unique resource that can be updated and curated in a decentralized manner, thereby accommodating the ever evolving field of aptamer research. DATABASE URL: http://aptamer.freebase.com. |
| Databáze: | OpenAIRE |
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