Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?
| Autor: | Grazia Tosone, Anna Maria Spera, Tarek Kamal Eldin, Raffaele Orlando |
|---|---|
| Přispěvatelé: | Spera, A. M., Eldin, T. K., Tosone, G., Orlando, R. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject Hepatitis C virus Population Breastfeeding Developing country Fertility Antiviral therapy medicine.disease_cause Pregnancy category 03 medical and health sciences 0302 clinical medicine Breastfeeding woman Medicine education media_common Gynecology Pregnancy education.field_of_study 030219 obstetrics & reproductive medicine Hepatology business.industry Obstetrics Minireviews Hepatitis C medicine.disease Directacting antiviral Hepatitis C virus infection 030211 gastroenterology & hepatology business |
| Popis: | Hepatitis C virus (HCV) affects about 3% of the world's population, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution (highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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