The Mammalian Golgi Regulates Numb Signaling in Asymmetric Cell Division by Releasing ACBD3 during Mitosis
| Autor: | Daria L. Bancescu, Haiyan Tang, Weimin Zhong, Yan Zhou, Pétur Henry Petersen, Kaiyong Zou, Sinead B. Stewart, Santiago B. Rompani, Joshua B. Atkins |
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| Rok vydání: | 2007 |
| Předmět: |
Embryo
Nonmammalian animal structures Cell division Embryonic Development Golgi Apparatus Mitosis Nerve Tissue Proteins DEVBIO Biology General Biochemistry Genetics and Molecular Biology MOLNEURO Animals Genetically Modified Mice symbols.namesake Cytosol STEMCELLS Asymmetric cell division Animals Cell Lineage Progenitor cell Adaptor Proteins Signal Transducing Neurons Biochemistry Genetics and Molecular Biology(all) Stem Cells fungi Membrane Proteins Cell cycle Golgi apparatus Embryo Mammalian Receptors GABA-A Neural stem cell Protein Structure Tertiary Cell biology Phenotype embryonic structures NUMB symbols Drosophila CELLBIO Cell Division hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Cell. 129(1):163-178 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2007.02.037 |
| Popis: | SummaryMammalian neural progenitor cells divide asymmetrically to self-renew and produce a neuron by segregating cytosolic Numb proteins primarily to one daughter cell. Numb signaling specifies progenitor over neuronal fates but, paradoxically, also promotes neuronal differentiation. Here we report that ACBD3 is a Numb partner in cell-fate specification. ACBD3 and Numb proteins interact through an essential Numb domain, and the respective loss- and gain-of-function mutant mice share phenotypic similarities. Interestingly, ACBD3 associates with the Golgi apparatus in neurons and interphase progenitor cells but becomes cytosolic after Golgi fragmentation during mitosis, when Numb activity is needed to distinguish the two daughter cells. Accordingly, cytosolic ACBD3 can act synergistically with Numb to specify cell fates, and its continuing presence during the progenitor cell cycle inhibits neuron production. We propose that Golgi fragmentation and reconstitution during cell cycle differentially regulate Numb signaling through changes in ACBD3 subcellular distribution and represent a mechanism for coupling cell-fate specification and cell-cycle progression. |
| Databáze: | OpenAIRE |
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