Effects of daily or weekly thermal (footpad) stress upon manifestation of melanoma tumours
| Autor: | Oksana Peredery, Gillian Duggan, Michael A. Persinger |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Pain Threshold Cellular immunity Melanoma Experimental Physiology Experimental and Cognitive Psychology medicine.disease_cause Mice Immune system Sex Factors Medicine Animals Latency (engineering) Skin Cell growth business.industry Melanoma medicine.disease Sensory Systems Hindlimb Mice Inbred C57BL Nociception Immunology Female Skin cancer business Carcinogenesis Skin Temperature Stress Psychological |
| Zdroj: | Perceptual and motor skills. 95(3 Pt 1) |
| ISSN: | 0031-5125 |
| Popis: | Summary.-A total of 48 C57 male and female mice received thermal stimulation to'their footpads either daily, weekly, or never. After either two or three weeks of this treatment the mice were injected to discern if the initiation of carcinogenic cell proliferation during a stressful period would influence the rate of development of the tumour. The latency in days for the onset of a discernable node over the injection site was measured. A statistically significant interaction between the temporal pattern of treatments and sex explained about 25% of the variance in the latency of the appearance of tumours. Posl hoc analysis showed the source of interaction involved the group that had not received the thermal stress. The results may suggest that either weekly or daily thermal stress may have reduced the females' resistance to tumorigenesis. However, this pattern and type of stress did not influence the first appearance of these skin tumours in the males. The temporal pattern of stimuli can influence the rate of cell division of aberrant cells within the body. For example, Sklar and Anisman (1979) found that a single nociceptive event (foot shock) facilitated tumour growth more than repeated nociceptive events. The present study was designed to discern if daily or weekly exposures to thermal nociception would affect the latency of the appearance of melanoma tumours, a form of skin cancer involving the abnormal growth of pigment-producing melanocytes. The selection of these two interstimulus intervals was based upon the response of the rodent's cellular immunity to single stressors (Missaghi, Richards, & Persinger, 1992). \Ve expected that the acute (daily) treatment would suppress the immune system and facilitate the growth of the mass of the rumour. A total of 48 male (n=24) and female (rz=24) C57 mice, 120 days of age at the beginning of the study, were subjects. Four mice of the same sex were maintained per cage. Water and food were available ad libitzim. Room temperature was controlled within 1' of 20' C. Equal numbers of male and Eemale mice were randomly assigned to one of three rreat |
| Databáze: | OpenAIRE |
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