Ambient air pollutants are associated with morning serum cortisol in overweight and obese Latino youth in Los Angeles

Autor: Claudia M. Toledo-Corral, Frank D. Gilliland, Alicia K Peterson, Frederick Lurmann, Michael I. Goran, Rima Habre, Tanya L. Alderete, Megan M. Herting, Mark J. Weigensberg
Rok vydání: 2021
Předmět:
Male
Time Factors
Cortisol awakening response
Adolescent
Hydrocortisone
Health
Toxicology and Mutagenesis
Nitrogen Dioxide
Hispanic
Physiology
010501 environmental sciences
Overweight
01 natural sciences
lcsh:RC963-969
03 medical and health sciences
Ozone
0302 clinical medicine
Humans
Medicine
Child
Children
0105 earth and related environmental sciences
Morning
Metabolic health
Pollutant
Air Pollutants
Serum cortisol
Ambient air pollution
business.industry
lcsh:Public aspects of medicine
Research
Public Health
Environmental and Occupational Health
lcsh:RA1-1270
Environmental Exposure
Fasting
Hispanic or Latino
Los Angeles
Ambient air
Cross-Sectional Studies
HPA-axis
lcsh:Industrial medicine. Industrial hygiene
Female
Particulate Matter
medicine.symptom
business
030217 neurology & neurosurgery
Zdroj: Environmental Health
Environmental Health, Vol 20, Iss 1, Pp 1-12 (2021)
ISSN: 1476-069X
Popis: Background Hypothalamic-pituitary-adrenal (HPA)-axis dysfunction has been associated with a variety of mental health and cardio-metabolic disorders. While causal models of HPA-axis dysregulation have been largely focused on either pre-existing health conditions or psychosocial stress factors, recent evidence suggests a possible role for central nervous system activation via air pollutants, such as nitrogen dioxide (NO2), ozone (O3) and particulate matter (PM). Therefore, in an observational study of Latino youth, we investigated if monthly ambient NO2, O3, and PM with aerodynamic diameter ≤ 2.5 (PM2.5) exposure were associated with morning serum cortisol levels. Methods In this cross-sectional study, morning serum cortisol level was assessed after a supervised overnight fast in 203 overweight and obese Latino children and adolescents (female/male: 88/115; mean age: 11.1 ± 1.7 years; pre-pubertal/pubertal/post-pubertal: 85/101/17; BMI z-score: 2.1 ± 0.4). Cumulative concentrations of NO2, O3 and PM2.5 were spatially interpolated at the residential addresses based on measurements from community monitors up to 12 months prior to testing. Single and multi-pollutant linear effects models were used to test the cumulative monthly lag effects of NO2, O3, and PM2.5 on morning serum cortisol levels after adjusting for age, sex, seasonality, social position, pubertal status, and body fat percent by DEXA. Results Single and multi-pollutant models showed that higher O3 exposure (derived from maximum 8-h exposure windows) in the prior 1–7 months was associated with higher serum morning cortisol (p 2.5 exposure (4–10 months) was associated with lower serum morning cortisol levels (p 2 over the 4–10 month exposure period associated with lower morning serum cortisol (p Conclusions Chronic ambient NO2, O3 and PM2.5 differentially associate with HPA-axis dysfunction, a mechanism that may serve as an explanatory pathway in the relationship between ambient air pollution and metabolic health of youth living in polluted urban environments. Further research that uncovers how ambient air pollutants may differentially contribute to HPA-axis dysfunction are warranted.
Databáze: OpenAIRE
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