Mortality and Associated Risk Factors in Dialysis Patients with Cardiovascular Disease

Autor: Xianyang Zhong, Feng Jie He, Hong Li, Zhengmao Luo, Manyi Liu, Junzhou Fu, Riguang Liu, Junrong Tong, Jun Zh. Huang
Rok vydání: 2016
Předmět:
Adult
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Population
030232 urology & nephrology
MEDLINE
Disease
030204 cardiovascular system & hematology
lcsh:RC870-923
Dialysis patients
Peritoneal dialysis (PD)
03 medical and health sciences
0302 clinical medicine
Renal Dialysis
Risk Factors
lcsh:Dermatology
medicine
Diabetes Mellitus
Humans
cardiovascular diseases
Prospective Studies
Mortality
Renal Insufficiency
Chronic
Prospective cohort study
Intensive care medicine
education
Survival analysis
Aged
Hemodialysis (HD)
education.field_of_study
business.industry
Case-control study
Follow up studies
General Medicine
lcsh:RL1-803
Middle Aged
Cardiovascular disease
lcsh:Diseases of the genitourinary system. Urology
Survival Analysis
Stroke
lcsh:RC666-701
Nephrology
Cardiovascular Diseases
Case-Control Studies
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Zdroj: Kidney & Blood Pressure Research, Vol 41, Iss 4, Pp 479-487 (2016)
ISSN: 1423-0143
Popis: Background/Aims: Although dialysis patients have a higher risk of morbidity and mortality related to cardiovascular disease (CVD) than the general population, the mortality and associated risk factors in Asian dialysis patients with CVD have not been well examined. Methods: In this prospective cohort study, mortality and risk factors were investigated in 591 dialysis patients who were recruited from two dialysis centers from May 1, 2009 to May 1, 2014. The Cox proportional hazards regression assessed adjusted differences in mortality risk. A multivariate analysis was also performed, comparing the CVD and non-CVD groups. Results: A total of 591 patients were enrolled in this study (mean age, 52.05 ± 16.46 years [SD]; 61.8% men; 20.8% with CVD), with a median follow-up of 21.9 (maximum, 72) months. The cumulative hazard of mortality was significantly higher in CVD patients (hazard ratio [HR], 1.835; 95% confidence interval [CI], 1.023-3.293; P=0.042) than in their non-CVD counterparts after adjusting for various confounders. On multivariate Cox analysis, stroke (HR, 4.574; 95% CI, 2.149-9.736; PConclusion: All-cause mortality was significantly higher in the CVD group than in the non-CVD group. Stroke is an independent risk factor for all-cause mortality in dialysis patients with CVD. These findings warrant further studies into preventive and interventional strategies.
Databáze: OpenAIRE
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