Copper(II)-Mediated Ring Opening/Alkynylation of Tertiary Cyclopropanols by Using Nonmodified Terminal Alkynes
| Autor: | Yan-Ying Cui, Bu-Qing Cheng, Weidong Rao, Guo-Zhi Han, Xue-Qiang Chu, Haiyan Xu, Zhi-Liang Shen, Si-Xuan Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry Alkyne chemistry.chemical_element 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Copper Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Alkynylation Yield (chemistry) Cyclopropanol Functional group Physical and Theoretical Chemistry |
| Zdroj: | Organic letters. 22(14) |
| ISSN: | 1523-7052 |
| Popis: | The copper(II)-mediated ring opening/alkynylation of cyclopropanol by employing inexpensive and commercially available terminal alkyne is developed. The reactions proceeded efficiently to afford synthetically useful alk-4-yn-1-ones in moderate to good yields with good functional group tolerance. Control experiments showed that the reaction presumably proceeds via the formation of intermediates of copper homoenolate and/or alkynylcopper species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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