Puerol and pueroside derivatives from Pueraria lobata and their anti-inflammatory activity

Autor:	Ying-Jie Sun, Shi-Jie Cao, Feng-Ni Liang, Jin-Yan Li, Xiang-Yu Zhang, Wei Li, Li-Qin Ding, Feng Qiu
Rok vydání:	2023
Předmět:	Pueraria Anti-Inflammatory Agents Plant Science General Medicine Horticulture Molecular Biology Biochemistry
Zdroj:	Phytochemistry. 205:113507
ISSN:	0031-9422
Popis:	Five undescribed puerols and puerosides and three known analogues were obtained from the roots of Pueraria lobata. Their structures were determined by comprehensive analysis of spectroscopic data and chemical methods. Since puerol D and puerol C were racemic compounds, resolved into their enantiomers, and their absolute configurations were determined by experimental and calculated ECD spectra. Six of the isolates were evaluated for their inhibitory activities on NO generation and the expression of inflammatory factors in the LPS-stimulated RAW 264.7 macrophage cells. The results showed that (S)-puerol C, (R)-puerol C, isokuzubutenolide A and kuzubutenolide A significantly decreased the NO production (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9746682f7797fc28217db629f5a236 https://doi.org/10.1016/j.phytochem.2022.113507 Zobrazit plný text záznamu Full Text from ScienceDirect