Epidural/spinal anesthesia during delivery in women with factor XI deficiency, a single center experience

Autor:	Uri Rozovski, Eran Hadar, Yuval Yaniv, Ester Ziv, Arnon Wiznitzer, Anat Shmueli, Galia Spectre, Leonid A. Eidelman, Adi Abulafia, Pia Raanani, Sharon Orbach-Zinger, Adi Borovich, Arza Steimatzky
Rok vydání:	2020
Předmět:	Anesthesia Epidural medicine.medical_specialty Factor XI Deficiency Population 030204 cardiovascular system & hematology Single Center Anesthesia Spinal 03 medical and health sciences 0302 clinical medicine Pregnancy Coagulation testing medicine Humans education Factor XI Genetics (clinical) education.field_of_study medicine.diagnostic_test Obstetrics business.industry Incidence (epidemiology) Pregnancy Complications Hematologic Hematology General Medicine medicine.disease Ashkenazi jews Jews Amniocentesis Female business 030215 immunology
Zdroj:	Haemophilia. 26:834-839
ISSN:	1365-2516 1351-8216
DOI:	10.1111/hae.14079
Popis:	INTRODUCTION The safety of neuro-axial anaesthesia (epidural/spinal) at labour of women with partial factor XI (FXI) deficiency is uncertain. Although FXI deficiency is frequent in Ashkenazi Jews, it is not routinely measured before labour. Our institute serves a large Ashkenazi population. We assumed that 10% of them have undiagnosed FXI deficiency. AIM Assess the incidence, bleeding tendency and coagulation status among Jewish Ashkenazi women with FXI deficiency that underwent neuro-axial anaesthesia at delivery. METHODS Jewish Ashkenazi women who underwent neuro-axial anaesthesia at labour completed the SSC ISTH bleeding assessment tool (BAT) and had blood drawn for coagulation tests, FXI and thrombin generation after labour. Estimation for 10 years was calculated from the 1-year sample. RESULTS We recruited 261 women during 12 months. Among them, 39 (15%) had FXI deficiency (
Databáze:	OpenAIRE
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