Synthesis and biological evaluation of aminoketones
| Autor: | U. Sankappa Rai, Hoong-Kun Fun, Arun M. Isloor, Nishitha Isloor, Prakash Shetty, Shridhar Malladi |
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| Rok vydání: | 2010 |
| Předmět: |
Models
Molecular Staphylococcus aureus medicine.drug_class Microbial Sensitivity Tests Crystallography X-Ray Chemical synthesis Catalysis Aminoketone Structure-Activity Relationship Drug Discovery medicine Escherichia coli Molecule Structure–activity relationship Organic chemistry Microwaves Mannich reaction Antibacterial agent Pharmacology Molecular Structure Chemistry Organic Chemistry General Medicine Ketones Antimicrobial Anti-Bacterial Agents Pseudomonas aeruginosa Bacillus subtilis |
| Zdroj: | European journal of medicinal chemistry. 45(12) |
| ISSN: | 1768-3254 |
| Popis: | A three-component Mannich reaction of different ketones with aromatic aldehydes and different amines in microwave irradiation under solvent free condition afforded corresponding β-amino carbonyl compounds in excellent yields. This method proved as a novel and improved modification of the reported three-component Mannich reaction in terms of milder reaction conditions, reaction times, clean reaction profiles, very small quantity of catalyst and simple workup procedure. Newly synthesized β-aminoketones were characterized by spectral studies. Structure of compound 4a was also confirmed by single-crystal X-ray analysis. All the compounds were screened for their antimicrobial activity by MIC method. Few of the molecules were found to be biologically potent. |
| Databáze: | OpenAIRE |
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