The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury
| Autor: | Melih Karabeyoglu, Ümer Cengiz, Istar Dolapci, Isil Karabeyoglu, Ayse Bilgihan, Bülent Ünal, Betül Bozkurt |
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| Rok vydání: | 2006 |
| Předmět: |
Burn injury
Pathology medicine.medical_specialty medicine.medical_treatment Ileum Spleen Pharmacology chemistry.chemical_compound Malondialdehyde medicine Mesenteric lymph nodes Animals Intestinal Mucosa Rats Wistar Pyruvates Saline Peroxidase Thermal injury business.industry medicine.disease Rats Intestines Oxidative Stress medicine.anatomical_structure chemistry Liver Bacterial Translocation Reperfusion Injury Surgery Lymph Nodes business Burns Reperfusion injury |
| Zdroj: | The Journal of surgical research. 144(1) |
| ISSN: | 0022-4804 |
| Popis: | Thermal injury causes a breakdown in the intestinal mucosal barrier due to ischemia reperfusion injury, which can induce bacterial translocation (BT), sepsis, and multiple organ failure in burn patients. The aim of this study was to investigate the effect of ethyl pyruvate (EP) on intestinal oxidant damage and BT in burn injury.Thirty-two rats were randomly divided into four groups. The sham group was exposed to 21 degrees C water and injected intraperitoneal with saline (1 mL/100 g). The sham + EP group received EP (40 mg/kg) intraperitoneally 6 h after the sham procedure. The burn group was exposed to thermal injury and given intraperitoneal saline injection (1 mL/100 g). The burn + EP group received EP (40 mg/kg) intraperitoneally 6 h after thermal injury. Twenty-four hours later, tissue samples were obtained from mesenteric lymph nodes, spleen, and liver for microbiological analysis and ileum samples were harvested for biochemical analysis.Thermal injury caused severe BT in burn group. EP supplementation decreased BT in mesenteric lymph nodes and spleen in the burn + EP group compared with the burn group (P0.05). Also, burn caused BT in liver, but this finding was not statistically significant among all groups. Thermal injury caused a statistically significant increase in malondialdehyde and myeloperoxidase levels, and EP prevented this effects in the burn + EP group compared with the burn group (P0.05).Our data suggested that EP can inhibit the BT and myeloperoxidase and malondialdehyde production in intestine following thermal injury, suggesting anti-inflammatory and anti-oxidant properties of EP. |
| Databáze: | OpenAIRE |
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