High-dose naltrexone therapy and dietary counseling for obesity
| Autor: | Mary C. Gannon, Dorothy K. Hatsukami, James E. Mitchell, John E. Morley, Allen S. Levine, David N. Pfohl |
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| Rok vydání: | 1987 |
| Předmět: |
Drug
Adult Counseling Male Diet Reducing media_common.quotation_subject Population Pharmacology Placebo Naltrexone Random Allocation Double-Blind Method Liver Function Tests Weight loss medicine Humans Obesity education Biological Psychiatry Endogenous opioid media_common education.field_of_study Narcotic antagonist business.industry Middle Aged Clinical trial medicine.symptom business medicine.drug |
| Zdroj: | Biological psychiatry. 22(1) |
| ISSN: | 0006-3223 |
| Popis: | There is considerable evidence that antagonism of the endogenous opioids will suppress food intake in a variety of animal species. The authors report a double-blind, placebo-controlled trial of the long-acting, orally active narcotic antagonist naltrexone in the promotion of weight loss in obese male subjects who were also undergoing dietary counseling for weight reduction. Subjects received medication (naltrexone, 300 mg/day or placebo) for 8 weeks following an initial 2-week single-blind placebo phase. The results failed to demonstrate an advantage for the active drug. However, the naltrexone was associated with hepatotoxicity when used at this dosage in this population. |
| Databáze: | OpenAIRE |
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